In the case of an allergic reaction, when should you administer antihistamines?

Administering antihistamines in the context of an allergic reaction is critical for effectively managing the symptoms associated with such reactions. The timing of antihistamine administration is particularly important.

In cases of anaphylaxis or severe allergic reactions, epinephrine is the first-line treatment due to its rapid action in countering life-threatening symptoms such as airway constriction, decreased blood pressure, and swelling. However, once epinephrine has been administered and if the symptoms persist—or following stabilization of the patient—antihistamines can then be given to address secondary symptoms like urticaria (hives) and itching.

This sequence allows for the immediate and appropriate treatment of acute symptoms with epinephrine, while antihistamines can help alleviate non-life-threatening discomfort once the patient's immediate risk has been managed. This is why administering antihistamines only after epinephrine, and if symptoms persist, is the correct approach in the management of allergic reactions.